Rated Charleston as best city in north America to travel and live by Travel magazine, the home prices of Charleston area became to soar. It is demanding from home buyers to address the factors affecting home prices in Charleston area. We selected several candidate factors contributing to the home prices: regions, number of bedrooms, number of bathrooms, square feet, median income, and waterfront view or not. The data are collected from a sample of 210 homes on Zillow. We fit data to a general linear model. Among the candidate factors, the analysis results show that all except the number of bedrooms/bathrooms significantly affect the home prices. We further apply the Bonferroni method for simultaneous testing of the region effects vs. the baseline effect of home prices from downtown Charleston. Even though the estimates of home prices of the non-downtown regions are lower than that of downtown, such difference is not significant between the pair Isle of Palms and downtown Charleston.